Genetic mechanisms of primary lung emphysema

Congenital Cyst and Emphysema of the Lung

Les auteurs rapportent chez deux nourrissons, l'etude anatomo-clinique d'un cas de kystes alveolaires multiples,et d'un cas d'emphyseme lobaire congenital bilateral.Le troisieme cas concerne un kyste bronchog6nique du poumon gauche,decouvert a l'autopsie d'un nouveau-ne. Dans le quatrieme cas,un emphyseme geant du lobe superieur gauche,decouvert dans un contexte infectieux,a l'age de neuf mois,...

Bullous Emphysema of the Lung

Static lung-lung interactions in unilateral emphysema.

Motivated by the introduction of single-lung transplantation into clinical practice, we compared the static mechanical properties of the respiratory system in six supine dogs before (at baseline) with those after the induction of unilateral emphysema. Relaxation volume (Vrel), total lung capacity (TLC), and static compliance of the emphysematous lung increased to 214 +/- 68, 186 +/- 39, and 253...

Lung density and lung mass in emphysema.

Mean lung density (dm) and radiologic (VLx) lung volume can be calculated using CT scan data. As many emphysematous patients are overdistended, the analysis of dm alone could be meaningless. However, lung mass (m) can be calculated as the product of dm and VLx. Twenty-four patients suspected of mild or severe emphysema as judged by roentgenographic and physiologic examinations as well as 16 hea...

Mechanisms of gas exchange response to lung volume reduction surgery in severe emphysema.

Lung volume reduction surgery (LVRS) improves lung function, respiratory symptoms, and exercise tolerance in selected patients with chronic obstructive pulmonary disease, who have heterogeneous emphysema. However, the reported effects of LVRS on gas exchange are variable, even when lung function is improved. To clarify how LVRS affects gas exchange in chronic obstructive pulmonary disease, 23 p...